Oncoscience

Correction: Targeting focal adhesion kinase overcomes erlotinib resistance in smoke induced lung cancer by altering phosphorylation of epidermal growth factor receptor

Hitendra S. Solanki1,2,*, Remya Raja1,*, Alex Zhavoronkov3, Ivan V. Ozerov3, Artem V. Artemov3, Jayshree Advani1,4, Aneesha Radhakrishnan1, Niraj Babu1,4, Vinuth N. Puttamallesh1,5, Nazia Syed1, Vishalakshi Nanjappa1, Tejaswini Subbannayya1, Nandini A. Sahasrabuddhe1, Arun H. Patil1,2,6, T.S. Keshava Prasad1,6,7, Daria Gaykalova8, Xiaofei Chang8, Rachana Sathyendran9, Premendu Prakash Mathur2, Annapoorni Rangarajan9, David Sidransky8, Akhilesh Pandey10,11,12,13, Evgeny Izumchenko8, Harsha Gowda1,6 and Aditi Chatterjee1,6

1 Institute of Bioinformatics, International Tech Park, Bangalore 560066, India

2 School of Biotechnology, Kalinga Institute of Industrial Technology, Bhubaneswar, Odisha 751024, India

3 Insilico Medicine, Inc., Emerging Technology Centers, Johns Hopkins University at Eastern, Baltimore, MD 21218, USA

4 Manipal Academy of Higher Education, Manipal, Karnataka 576104, India

5 School of Biotechnology, Amrita University, Kollam 690525, India

6 Center for Systems Biology and Molecular Medicine, Yenepoya (Deemed to be University), Mangalore 575018, India

7 NIMHANS-IOB Proteomics and Bioinformatics Laboratory, Neurobiology Research Centre, National Institute of Mental Health and Neurosciences, Bangalore 560029, India

8 Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA

9 Department of Molecular Reproduction, Development and Genetics, Indian Institute of Science, Bangalore, 560012, India

10 McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA

11 Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA

12 Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA

13 Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA

* These authors contributed equally to the manuscript

Published: September 23, 2021

Copyright: © 2021 Solanki et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

This article has been corrected: Due to errors during figure assembly, the image for panel 3, column 1 in Figure 4B is an accidental duplicate of the image in panel 3, column 1 of Figure 4A. The corrected Figure 4 is shown below. The authors declare that these corrections do not change the results or conclusions of this paper.

Original article: Oncoscience. 2018 Feb 23;5(1-2):21–38

PMCID: PMC5854290 PMID: 29556515

DOI: 10.18632/oncoscience.395

Figure 4
Inhibition of FAK decreases the invasive property of lung cancer cells.
Invasion assays were carried out in a transwell system using Matrigel-coated filters and the number of cells that migrated to the lower chamber was counted. Cells that migrated are visualized following methylene blue staining in H358-S and NSCLC cell lines, H1299 and H1650 as indicated. (A) Cells were treated with either DMSO (vehicle control) or PF-562271 and invaded cells were photographed. Representative images were photographed at a magnification 10x. Invaded cells were counted and relative changes in invasive ability of H358-S and NSCLC cells upon inhibition with PF-562271 was calculated and represented graphically (*p < 0.05). (B) Cells were transfected with either scrambled siRNA or FAK siRNA and invaded cells were photographed. Invaded cells were counted and relative changes in invasive ability of H358-S and NSCLC cells upon FAK silencing was calculated and represented graphically (*p < 0.05). Representative images were photographed at a magnification 10x.
Figure 4: Inhibition of FAK decreases the invasive property of lung cancer cells.