Biological role of miR-204 and miR-211 in melanoma
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https://doi.org/10.18632/oncoscience.443
Marianna Vitiello1,2, Romina D’Aurizio3, Laura Poliseno1,2
1Oncogenomics Unit, CRL-ISPRO, 56124 Pisa, Italy
2Institute of Clinical Physiology, CNR, 56124 Pisa, Italy
3Institute of Informatics and Telematics, CNR, 56124 Pisa, Italy
Correspondence to:
Laura Poliseno, email:[email protected]
Marianna Vitiello, email:[email protected]
Keywords: melanoma, small RNA-seq, BRAF inhibitors, miR-204, miR-211
Received: March 28, 2018 Accepted: May 18, 2018 Published: August 22, 2018
Abstract
In this short report, we pinpoint some technical and conceptual flaws that we found in the article entitled “miR-204-5p and miR-211-5p contribute to BRAF inhibitor resistance in melanoma” (Díaz-Martínez et al., Cancer Research 2018). We also discuss how, in our opinion, these flaws led Díaz-Martínez and colleagues to incorrect conclusions about the biological role that miR-204 and miR-211 play in melanoma and about the terms of their involvement in the phenomenon of resistance to BRAF inhibitors.
PII: 443
